Presentation Title

Nitrite Reduction by a PDI Complex with a Proton-Responsive Secondary Coordination Sphere

Presentation Type

Poster

Abstract

Nitric oxide (NO) plays a key role in biological systems as a messenger molecule for regulating immune function, serving as a neurotransmitter in the brain, and for activating iron regulatory factors in macrophages. Nitrite reduction to NO is a viable route for the investigation of complexes capable of mimicking the biological production of NO. NO targets metal-containing proteins which can lead to the formation of dinitrosyl iron complexes (DNICs). To investigate this reaction, iron (II) pyridinediimine complexes with pendant bases in the secondary coordination sphere were synthesized. The complexes were characterized through infrared (IR) spectrometry, Mössbauer spectroscopy, and X-ray crystallography. Additionally, these complexes were reduced and protonated at the pendant base for the generation of complexes capable of both proton and electron transfer for the reduction of nitrite to NO.

Start Date

6-5-2017 12:15 PM

End Date

6-5-2017 2:00 PM

Location

Miller Hall

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May 6th, 12:15 PM May 6th, 2:00 PM

Nitrite Reduction by a PDI Complex with a Proton-Responsive Secondary Coordination Sphere

Miller Hall

Nitric oxide (NO) plays a key role in biological systems as a messenger molecule for regulating immune function, serving as a neurotransmitter in the brain, and for activating iron regulatory factors in macrophages. Nitrite reduction to NO is a viable route for the investigation of complexes capable of mimicking the biological production of NO. NO targets metal-containing proteins which can lead to the formation of dinitrosyl iron complexes (DNICs). To investigate this reaction, iron (II) pyridinediimine complexes with pendant bases in the secondary coordination sphere were synthesized. The complexes were characterized through infrared (IR) spectrometry, Mössbauer spectroscopy, and X-ray crystallography. Additionally, these complexes were reduced and protonated at the pendant base for the generation of complexes capable of both proton and electron transfer for the reduction of nitrite to NO.