Presentation Title
Nitrite Reduction by a PDI Complex with a Proton-Responsive Secondary Coordination Sphere
Presentation Type
Poster
Abstract
Nitric oxide (NO) plays a key role in biological systems as a messenger molecule for regulating immune function, serving as a neurotransmitter in the brain, and for activating iron regulatory factors in macrophages. Nitrite reduction to NO is a viable route for the investigation of complexes capable of mimicking the biological production of NO. NO targets metal-containing proteins which can lead to the formation of dinitrosyl iron complexes (DNICs). To investigate this reaction, iron (II) pyridinediimine complexes with pendant bases in the secondary coordination sphere were synthesized. The complexes were characterized through infrared (IR) spectrometry, Mössbauer spectroscopy, and X-ray crystallography. Additionally, these complexes were reduced and protonated at the pendant base for the generation of complexes capable of both proton and electron transfer for the reduction of nitrite to NO.
Start Date
6-5-2017 12:15 PM
End Date
6-5-2017 2:00 PM
Genre/Form
posters
Subjects - Topical (LCSH)
Nitric oxide; Nitrites; Immune system; Iron
Type
Event
Format
application/pdf
Language
English
Nitrite Reduction by a PDI Complex with a Proton-Responsive Secondary Coordination Sphere
Miller Hall
Nitric oxide (NO) plays a key role in biological systems as a messenger molecule for regulating immune function, serving as a neurotransmitter in the brain, and for activating iron regulatory factors in macrophages. Nitrite reduction to NO is a viable route for the investigation of complexes capable of mimicking the biological production of NO. NO targets metal-containing proteins which can lead to the formation of dinitrosyl iron complexes (DNICs). To investigate this reaction, iron (II) pyridinediimine complexes with pendant bases in the secondary coordination sphere were synthesized. The complexes were characterized through infrared (IR) spectrometry, Mössbauer spectroscopy, and X-ray crystallography. Additionally, these complexes were reduced and protonated at the pendant base for the generation of complexes capable of both proton and electron transfer for the reduction of nitrite to NO.