Poster Title

Synthetic Studies on Guaipyridine Alkaloids: Intramolecular Heck Approach

Co-Author(s)

Patrick Shelton, James Vyvyan

Research Mentor(s)

James Vyvyan

Affiliated Department

Chemistry

Sort Order

49

Start Date

14-5-2015 10:00 AM

End Date

14-5-2015 2:00 PM

Document Type

Event

Abstract

Guaipyridine alkaloids are a rare family of natural products characterized by a pyridine-fused cycloheptane structure. Examples include cananodine, isolated from Cananga odorata, and the rupestines, isolated from Artemesia rupestris. We have previously explored the creation of the pyridine-fused cycloheptane core using an intramolecular epoxide opening. Here we present our results using an intramolecular Heck coupling approach to the seven-membered ring of the guaipyridine targets.

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May 14th, 10:00 AM May 14th, 2:00 PM

Synthetic Studies on Guaipyridine Alkaloids: Intramolecular Heck Approach

Chemistry

Guaipyridine alkaloids are a rare family of natural products characterized by a pyridine-fused cycloheptane structure. Examples include cananodine, isolated from Cananga odorata, and the rupestines, isolated from Artemesia rupestris. We have previously explored the creation of the pyridine-fused cycloheptane core using an intramolecular epoxide opening. Here we present our results using an intramolecular Heck coupling approach to the seven-membered ring of the guaipyridine targets.