Synthetic Studies on Guaipyridine Alkaloids: Intramolecular Heck Approach
Research Mentor(s)
Vyvyan, James R.
Description
Guaipyridine alkaloids are a rare family of natural products characterized by a pyridine-fused cycloheptane structure. Examples include cananodine, isolated from Cananga odorata, and the rupestines, isolated from Artemesia rupestris. We have previously explored the creation of the pyridine-fused cycloheptane core using an intramolecular epoxide opening. Here we present our results using an intramolecular Heck coupling approach to the seven-membered ring of the guaipyridine targets.
Document Type
Event
Start Date
14-5-2015 10:00 AM
End Date
14-5-2015 2:00 PM
Department
Chemistry
Genre/Form
student projects; posters
Subjects – Topical (LCSH)
Alkaloids--Synthesis; Organic compounds--Synthesis
Type
Image
Rights
Copying of this document in whole or in part is allowable only for scholarly purposes. It is understood, however, that any copying or publication of this documentation for commercial purposes, or for financial gain, shall not be allowed without the author's written permission.
Language
English
Format
application/pdf
Synthetic Studies on Guaipyridine Alkaloids: Intramolecular Heck Approach
Guaipyridine alkaloids are a rare family of natural products characterized by a pyridine-fused cycloheptane structure. Examples include cananodine, isolated from Cananga odorata, and the rupestines, isolated from Artemesia rupestris. We have previously explored the creation of the pyridine-fused cycloheptane core using an intramolecular epoxide opening. Here we present our results using an intramolecular Heck coupling approach to the seven-membered ring of the guaipyridine targets.