Event Title

Performance of biocompatible silk-polypyrrole actuators under biologically relevant conditions

Research Mentor(s)

Janelle Leger

Description

Biocompatible actuators that are capable of controlled movement and can function under biologically relevant conditions are of significant interest for biomedical applications. Previously, we demonstrated that a composite of silk biopolymer and the conducting polymer poly(pyrrole) (PPy) can be formed into a functional bilayer bending actuator. These silk-PPy composites can generate forces comparable to human muscle (>0.1 MPa) making them ideal candidates for interfacing with biological tissues. We explore the performance of these silk-PPy bilayer actuators under biologically relevant conditions including exposure to protein, serum, enzymes, and biologically relevant temperatures. Free-end bending actuation performance, current response, force generation, and mass degradation under these conditions were investigated. We find that the performance of our silk-PPy devices is sensitive to protein serum and enzyme type, as well as the temperature at which the devices are actuated. However, the silk-PPy actuators under all conditions tested here retained the ability to bend, generate forces, and conduct currents at comparable levels to devices tested under standard operating conditions. The results suggest that our silk-PPy actuators are promising candidates for implantation in vivo and for interfacing with biological systems.

Document Type

Event

Start Date

17-5-2018 9:00 AM

End Date

17-5-2018 12:00 PM

Location

Physics and Astronomy

Rights

Copying of this document in whole or in part is allowable only for scholarly purposes. It is understood, however, that any copying or publication of this documentation for commercial purposes, or for financial gain, shall not be allowed without the author's written permission.

Language

English

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May 17th, 9:00 AM May 17th, 12:00 PM

Performance of biocompatible silk-polypyrrole actuators under biologically relevant conditions

Physics and Astronomy

Biocompatible actuators that are capable of controlled movement and can function under biologically relevant conditions are of significant interest for biomedical applications. Previously, we demonstrated that a composite of silk biopolymer and the conducting polymer poly(pyrrole) (PPy) can be formed into a functional bilayer bending actuator. These silk-PPy composites can generate forces comparable to human muscle (>0.1 MPa) making them ideal candidates for interfacing with biological tissues. We explore the performance of these silk-PPy bilayer actuators under biologically relevant conditions including exposure to protein, serum, enzymes, and biologically relevant temperatures. Free-end bending actuation performance, current response, force generation, and mass degradation under these conditions were investigated. We find that the performance of our silk-PPy devices is sensitive to protein serum and enzyme type, as well as the temperature at which the devices are actuated. However, the silk-PPy actuators under all conditions tested here retained the ability to bend, generate forces, and conduct currents at comparable levels to devices tested under standard operating conditions. The results suggest that our silk-PPy actuators are promising candidates for implantation in vivo and for interfacing with biological systems.