Event Title

The Synthesis of Optically Pure Cananodine

Research Mentor(s)

James Vyvyan

Description

The objective of my research is to synthesize cananodine (6)(Scheme 1). Cananodine is an alkaloid extracted from the fruits of the Cananga odorata (ylang-ylang) tree and is found to be active against two types of liver cancer cells: Hep G2 and Hep 2,2,15. It is important to develop new therapies against liver cancer because almost all chemotherapies for liver cancer have low response rates and have not shown increased survival times. The leading drug to treat liver cancer is sorafenib and only increases the patient’s life span for 2.8 months. Cananodine has been found to have an activity greater than the vitro potency of sorafenib, so it is my goal to synthesize it for biological assay.

Document Type

Event

Start Date

May 2018

End Date

May 2018

Location

Chemistry

Rights

Copying of this document in whole or in part is allowable only for scholarly purposes. It is understood, however, that any copying or publication of this document for commercial purposes, or for financial gain, shall not be allowed without the author’s written permission.

Language

English

Format

application/pdf

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May 17th, 9:00 AM May 17th, 12:00 PM

The Synthesis of Optically Pure Cananodine

Chemistry

The objective of my research is to synthesize cananodine (6)(Scheme 1). Cananodine is an alkaloid extracted from the fruits of the Cananga odorata (ylang-ylang) tree and is found to be active against two types of liver cancer cells: Hep G2 and Hep 2,2,15. It is important to develop new therapies against liver cancer because almost all chemotherapies for liver cancer have low response rates and have not shown increased survival times. The leading drug to treat liver cancer is sorafenib and only increases the patient’s life span for 2.8 months. Cananodine has been found to have an activity greater than the vitro potency of sorafenib, so it is my goal to synthesize it for biological assay.