Event Title

Determining which cells actively produce UBC-6 and UBC-7 within C. elegans

Research Mentor(s)

Lina Dahlberg

Description

A number of neurodegenerative diseases involve the accumulation of misfolded proteins into various forms of aggregation. These protein aggregates play a key role in the pathogenesis of diseases such as Parkinson’s and Alzheimer’s. We know that the Endoplasmic Reticulum, an organelle located inside the cell, is responsible for managing the production and destruction of certain proteins, however the exact mechanism of this regulation process is not fully understood. Ubiquitin ligases are types of proteins that chemically mark misfolded proteins to be destroyed to avoid protein build up. Our lab studies the role of Ubiquitin ligases in the process of protein degradation in the model organism Caenorhabditis elegans, microscopic worms. Specifically, our work focuses on Ubiquitin ligase UBC-6 and UBC-7 and determining which cells actively produce these proteins.

Document Type

Event

Start Date

17-5-2018 9:00 AM

End Date

17-5-2018 12:00 PM

Location

Biology

Rights

Copying of this document in whole or in part is allowable only for scholarly purposes. It is understood, however, that any copying or publication of this documentation for commercial purposes, or for financial gain, shall not be allowed without the author's written permission.

Language

English

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May 17th, 9:00 AM May 17th, 12:00 PM

Determining which cells actively produce UBC-6 and UBC-7 within C. elegans

Biology

A number of neurodegenerative diseases involve the accumulation of misfolded proteins into various forms of aggregation. These protein aggregates play a key role in the pathogenesis of diseases such as Parkinson’s and Alzheimer’s. We know that the Endoplasmic Reticulum, an organelle located inside the cell, is responsible for managing the production and destruction of certain proteins, however the exact mechanism of this regulation process is not fully understood. Ubiquitin ligases are types of proteins that chemically mark misfolded proteins to be destroyed to avoid protein build up. Our lab studies the role of Ubiquitin ligases in the process of protein degradation in the model organism Caenorhabditis elegans, microscopic worms. Specifically, our work focuses on Ubiquitin ligase UBC-6 and UBC-7 and determining which cells actively produce these proteins.