Synthesis and characterization of PLGA capped gold nanoparticles for use in cancer therapeutics
Research Mentor(s)
Dr. David A. Rider
Description
This research project aims to create gold nanoparticles (AuNPs) functionalized with PLGA (poly(lactic co-glycolic acid)) polymers for generating reactive oxygen species (ROS) by way of X-ray irradiation for use in cancer therapies.1–3 The current methods of cancer treatment rely on drugs and/or chemotherapy depending on the type of cancer present; these methods come with varying success rates which are also dependent on how severe the condition has become (the lower the severity, the higher chance of success). By using appropriately functionalized AuNPs, they can be sent to the site of the tumor where they can be irradiated with X-rays to generate ROS to destroy cancer cells; to increase the compatibility of the functionalized AuNPs, they co-precipitated with water soluble poly(vinyl alcohol) (PVA). By using a photosensitizer 1,3-diphenylisobenzofuran (DPBF) dissolved with the functionalized AuNPs, we can determine the quantum yield of ROS generation via UV/Vis spectrometry.6,7
Document Type
Event
Start Date
May 2022
End Date
May 2022
Location
Carver Gym (Bellingham, Wash.)
Department
CSE - Chemistry
Genre/Form
student projects; posters
Type
Image
Rights
Copying of this document in whole or in part is allowable only for scholarly purposes. It is understood, however, that any copying or publication of this document for commercial purposes, or for financial gain, shall not be allowed without the author’s written permission.
Language
English
Format
application/pdf
Synthesis and characterization of PLGA capped gold nanoparticles for use in cancer therapeutics
Carver Gym (Bellingham, Wash.)
This research project aims to create gold nanoparticles (AuNPs) functionalized with PLGA (poly(lactic co-glycolic acid)) polymers for generating reactive oxygen species (ROS) by way of X-ray irradiation for use in cancer therapies.1–3 The current methods of cancer treatment rely on drugs and/or chemotherapy depending on the type of cancer present; these methods come with varying success rates which are also dependent on how severe the condition has become (the lower the severity, the higher chance of success). By using appropriately functionalized AuNPs, they can be sent to the site of the tumor where they can be irradiated with X-rays to generate ROS to destroy cancer cells; to increase the compatibility of the functionalized AuNPs, they co-precipitated with water soluble poly(vinyl alcohol) (PVA). By using a photosensitizer 1,3-diphenylisobenzofuran (DPBF) dissolved with the functionalized AuNPs, we can determine the quantum yield of ROS generation via UV/Vis spectrometry.6,7