Research Mentor(s)
Dr. James Vyvyan
Description
Hepatocellular carcinoma (HCC) accounts for 75-85% of liver cancer diagnosis, effecting around 672,000 patients annually. Cananodine, a member of the guaipyridine family, has potential for bioactivity against cell lines of HCC. In the guaipyridine alkaloid family of rupestines A-M, the synthesis of rupestines L and M have not been completed. Rupestines L and M are the target molecules for this study. The structure of guaipyridines are composed of a seven-membered ring fused to a pyridine group, with varying functional groups and stereochemistry. The pathway to rupestines L and M will provide another route to test for the treatment of cancer. In this research, I provide progress in the synthesis towards rupestines L and M.
Document Type
Event
Start Date
May 2022
End Date
May 2022
Location
Carver Gym (Bellingham, Wash.)
Department
CSE - Chemistry
Genre/Form
student projects; posters
Type
Image
Rights
Copying of this document in whole or in part is allowable only for scholarly purposes. It is understood, however, that any copying or publication of this document for commercial purposes, or for financial gain, shall not be allowed without the author’s written permission.
Language
English
Format
application/pdf
Studies Towards Rupestines L and M
Carver Gym (Bellingham, Wash.)
Hepatocellular carcinoma (HCC) accounts for 75-85% of liver cancer diagnosis, effecting around 672,000 patients annually. Cananodine, a member of the guaipyridine family, has potential for bioactivity against cell lines of HCC. In the guaipyridine alkaloid family of rupestines A-M, the synthesis of rupestines L and M have not been completed. Rupestines L and M are the target molecules for this study. The structure of guaipyridines are composed of a seven-membered ring fused to a pyridine group, with varying functional groups and stereochemistry. The pathway to rupestines L and M will provide another route to test for the treatment of cancer. In this research, I provide progress in the synthesis towards rupestines L and M.