Solid Lipid Nanoparticles by sonicated”Phase Inversion Temperature” method – featuring alkenones
Research Mentor(s)
David Rider
Description
Solid Lipid nanoparticles (SLN) are currently being researched for medical applications and are currently used for topical applications like sunscreen. As the world is weaning away from synthesized or petroleum-based products, alkenones were selected as a biobased wax that can create solid lipid nanoparticles effectively. The phase inversion temperature method or (PIT) was chosen as a basis for our fabrication technique due to its simplicity, however it was found that it could be difficult to achieve monomodal distributions of lipid nanoparticles. The PIT method which was mechanically stirred via vortex machine was modified to include probe sonication. Here monomodal nanoparticle distributions could made from many waxes of despite their molecular differences, with distribution peaks ranging from 20-40 nm in diameter. Alkenones in general made particles 20-30 nm, signifying it that is one of the more capable SLN wax materials where generic paraffin candle wax on the lower end in terms of size. Also, some comparisons were made for encapsulation efficiency with Nile Red which showcases a wax’s potential to encapsulate pharmacological and cosmetic drugs.
Document Type
Event
Start Date
May 2022
End Date
May 2022
Location
Carver Gym (Bellingham, Wash.)
Department
CSE - Chemistry
Genre/Form
student projects; posters
Type
Image
Rights
Copying of this document in whole or in part is allowable only for scholarly purposes. It is understood, however, that any copying or publication of this document for commercial purposes, or for financial gain, shall not be allowed without the author’s written permission.
Language
English
Format
application/pdf
Solid Lipid Nanoparticles by sonicated”Phase Inversion Temperature” method – featuring alkenones
Carver Gym (Bellingham, Wash.)
Solid Lipid nanoparticles (SLN) are currently being researched for medical applications and are currently used for topical applications like sunscreen. As the world is weaning away from synthesized or petroleum-based products, alkenones were selected as a biobased wax that can create solid lipid nanoparticles effectively. The phase inversion temperature method or (PIT) was chosen as a basis for our fabrication technique due to its simplicity, however it was found that it could be difficult to achieve monomodal distributions of lipid nanoparticles. The PIT method which was mechanically stirred via vortex machine was modified to include probe sonication. Here monomodal nanoparticle distributions could made from many waxes of despite their molecular differences, with distribution peaks ranging from 20-40 nm in diameter. Alkenones in general made particles 20-30 nm, signifying it that is one of the more capable SLN wax materials where generic paraffin candle wax on the lower end in terms of size. Also, some comparisons were made for encapsulation efficiency with Nile Red which showcases a wax’s potential to encapsulate pharmacological and cosmetic drugs.