Cell specific ERAD rescue is C. elegans
Research Mentor(s)
Lina Dahlberg
Description
Endoplasmic Reticulum Associated Degradation (ERAD) is a key system for preventing the buildup of misfolded proteins. ERAD uses 3 classes of proteins, E1s, E2s, and E3s--in coordination to tag misfolded proteins, to signals for their degradation. Previous work from our laboratory suggests that a transmembrane protein, ODR-10, is regulated by the E3 HRDL-1, and the E2s UBC-6 and UBC-7. I have continued the investigation into the interactions between these proteins by creating strains where each gene of interest is only expressed in certain cells.
Document Type
Event
Start Date
May 2022
End Date
May 2022
Location
Carver Gym (Bellingham, Wash.)
Department
GS - Student/Faculty Designed–M.S.
Genre/Form
student projects; posters
Type
Image
Rights
Copying of this document in whole or in part is allowable only for scholarly purposes. It is understood, however, that any copying or publication of this document for commercial purposes, or for financial gain, shall not be allowed without the author’s written permission.
Language
English
Format
application/pdf
Cell specific ERAD rescue is C. elegans
Carver Gym (Bellingham, Wash.)
Endoplasmic Reticulum Associated Degradation (ERAD) is a key system for preventing the buildup of misfolded proteins. ERAD uses 3 classes of proteins, E1s, E2s, and E3s--in coordination to tag misfolded proteins, to signals for their degradation. Previous work from our laboratory suggests that a transmembrane protein, ODR-10, is regulated by the E3 HRDL-1, and the E2s UBC-6 and UBC-7. I have continued the investigation into the interactions between these proteins by creating strains where each gene of interest is only expressed in certain cells.