Senior Project Advisor
RNA, ciliate, Piwi genes
The world of RNA is vast and multifaceted. Messenger RNA is the most well understood of these molecules, however it is far from the only one. New classes of RNAs are of much interest to researchers due to both the functions that they play in organisms and the possibility of using them as research tools. Under the umbrella of RNA fall RNAs that are involved in RNA interference (RNAi) pathways. These RNAs are numerous, and some have already been shown to be deeply important to proper organismal function. A previously established ~23-24 nucleotide small RNA pathway in Tetrahymena thermophila has been recently linked to genome integrity (Lee et al., 2021). However, the full extent of the role this pathway plays is not yet known. In addition, the specific roles of different parts of the pathway are still not fully understood. With this information laid out, I attempt to synthesize the known information about this pathway and lay out methods used to investigate the connection to genome stability.
Ruddick, Abigail, "An Overview of Background and Experimental Methods Used to Investigate a ~23-24 nucleotide small RNA pathway and its Links to Genome Stability" (2023). WWU Honors College Senior Projects. 678.
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