Document Type

Project

Publication Date

6-2018

Keywords

Drosophila, GAL4-UAS, Mocs1, Lifespan, Longevity, Gene upregulation

Abstract

Molybdenum-cofactor biosynthesis protein 1 catalyzes the first step in the synthesis of molybdenum cofactor (Moco), which is conserved across taxa and present both in prokaryotes and in eukaryotes. The effects of Mocs1 -upregulation on Drosophila lifespan were determined using the GAL4-UAS system to drive Mocs1 expression. Driven females lived significantly longer than controls (p=5.7x10 -6 , p=9.0x10 -4 ) while males did not show increased lifespan (p=0.49, p=1.8x10 -5 ). The data suggest a link between Mocs1 and lifespan which has not been previously explored.

Type

Text

Rights

Copying of this document in whole or in part is allowable only for scholarly purposes. It is understood, however, that any copying or publication of this document for commercial purposes, or for financial gain, shall not be allowed without the author’s written permission.

Language

English

Format

application/pdf

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