Drosophila, GAL4-UAS, Mocs1, Lifespan, Longevity, Gene upregulation
Molybdenum-cofactor biosynthesis protein 1 catalyzes the first step in the synthesis of molybdenum cofactor (Moco), which is conserved across taxa and present both in prokaryotes and in eukaryotes. The effects of Mocs1 -upregulation on Drosophila lifespan were determined using the GAL4-UAS system to drive Mocs1 expression. Driven females lived significantly longer than controls (p=5.7x10 -6 , p=9.0x10 -4 ) while males did not show increased lifespan (p=0.49, p=1.8x10 -5 ). The data suggest a link between Mocs1 and lifespan which has not been previously explored.
Lee, Michael, "An Analysis of the effects of Mocs1 upregulation on lifespan in Drosophila melanogaster" (2018). WWU Honors Program Senior Projects. 85.
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