Conductive polymer, Peptide, Hydrogel, Beta-sheet
Here, we have taken a bottom-up approach to confer multidimensional structure to conductive polymers by attaching thiophene monomers to peptides predicted to self-assemble into a biomimetic, fibrous nanostructure. A library of 12 peptides containing covalently attached thiophene-based monomers was synthesized. Peptide sequences that resulted in self-assembly and hydrogel formation in aqueous media were identified and the physical and electrical properties were characterized. The resulting hybrid materials have conductivities in the range of 10-2-10-3 S/cm, and possess moduli in the range of several tissue types, making them potential candidates for use in biomedical electronic applications.
James, Ellie I., "Exploration of Peptide-Thiophene Hybrids as Self-Assembling Conductive Hydrogels" (2018). WWU Honors Program Senior Projects. 92.
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