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Date Permissions Signed
Date of Award
Department or Program Affiliation
Master of Science (MS)
Emory, Steven R.
Rider, David A. (Materials scientist)
Bao, Ying (Materials scientist)
In this study, pH-responsive microgel particles, comprised of 2-vinyl pyridine (P2VP) and styrene (PS), are explored as scaffolds to assemble metallic nanoparticles (NPs) for ultrasensitive detection strategies. Microgel particles serve as size-tunable scaffolds to assemble metal (silver or gold) NPs for surface-enhanced Raman scattering (SERS) vibrational spectroscopy. The high sensitivity of SERS arises from the enormous enhancement of the Raman scattering cross sections of molecules adsorbed to roughened metal surfaces, such as metal NPs. Using a sterically stabilized latex of random copolymers of PS and P2VP (PSxP2VPy), this polymer is capable of transitioning to a microgel state through acid-base titration. This effect can be used to manipulate the interparticle spacing between adsorbed metal NPs in order to optimize SERS enhancement. The size of these metal NPs, usually gold or silver (Au NPs or Ag NPs), can also be tuned to further optimize SERS enhancement. These microgel-NP composites are characterized and their pH-responsive behavior is demonstrated to be reversible in both bulk SERS and single-particle SERS analyses.
polymer, SERS, SERRS, pH
Western Washington University
Subject – LCSH
Microgels; Nanoparticles; Silver; Gold; Raman effect, Surface enhanced; Raman spectroscopy; Nanostructured materials
Copying of this document in whole or in part is allowable only for scholarly purposes. It is understood, however, that any copying or publication of this thesis for commercial purposes, or for financial gain, shall not be allowed without the author's written permission.
Silva, Alyson, "Multifunctional Microgels for Nanoparticle-Based Detection Methodologies" (2019). WWU Graduate School Collection. 874.