Senior Project Advisor

Josh Kaplan

Document Type

Project

Publication Date

Spring 2024

Keywords

Cannabis, Cannabidiol (CBD), Beta-caryophyllene, Allodynia, Von Frey Nociception Test

Abstract

This research explores the effects of cannabidiol (CBD) and beta-caryophyllene (BC; two phytochemicals produced by the plant, Cannabis sativa L.) on stress-induced allodynia in mice. Stress causes a body-wide inflammatory response that can lead to allodynia, which is a painful response to previously innocuous stimuli. Current treatments for stress-induced inflammation can have unwanted effects and addictive potential, creating a need for alternatives. To explore the therapeutic effects of CBD and BC, wildtype and BTBR mice were tested for sensitivity to mechanical stimuli using the Von Frey Nociception Test. The results reveal that both CBD and BC individually show potential as treatments for stress-induced allodynia, however CBD and BC do not appear to act in conjunction to treat stress-induced allodynia. Additionally, this study shows that CBD exposure increases stress-induced allodynia in female BTBR mice when administered as a preventative treatment. Together, our findings suggest that the efficacy of these phytochemicals against stress-induced allodynia depends on whether they are being used preventatively or following the stressful event.

[An explanation of the poster at the link is included as a supplemental file below]

Department

Psychology

Type

Text

Rights

Copying of this document in whole or in part is allowable only for scholarly purposes. It is understood, however, that any copying or publication of this document for commercial purposes, or for financial gain, shall not be allowed without the author’s written permission.

Language

English

Format

application/pdf

Additional Files
Player capstone poster description .docx (24 kB)
Explanation of poster
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