Synthesis and Evaluation of Sortase A Inhibitors
Research Mentor(s)
Murphy, Amanda R.
Description
Each year, an increasing number of antibiotics become less effective in combating infectious bacterial diseases as a result of the prolonged and wide spread use of these drugs as treatments. As a result of an increasing number of drug resistant strains of bacteria, at least 2 million people in the United States acquire infectious diseases from drug resistant bacteria each year that are potentially fatal according to the Centers for Disease Control and Prevention (CDC). Although combating drug resistance is a multifaceted strategy, the key to resolving this issue is through the development of new antibiotics. The preliminary evaluation of novel epoxide derivative drugs targeted against sortase A involved in the pathogenesis of the foodborne bacteria Listeria monocytogenes will be presented.
Document Type
Event
Start Date
16-5-2018 9:00 AM
End Date
16-5-2018 12:00 PM
Department
Chemistry
Genre/Form
student projects, posters
Subjects – Topical (LCSH)
Antibiotics; Drug resistance
Type
Image
Rights
Copying of this document in whole or in part is allowable only for scholarly purposes. It is understood, however, that any copying or publication of this document for commercial purposes, or for financial gain, shall not be allowed without the author’s written permission.
Language
English
Format
application/pdf
Synthesis and Evaluation of Sortase A Inhibitors
Each year, an increasing number of antibiotics become less effective in combating infectious bacterial diseases as a result of the prolonged and wide spread use of these drugs as treatments. As a result of an increasing number of drug resistant strains of bacteria, at least 2 million people in the United States acquire infectious diseases from drug resistant bacteria each year that are potentially fatal according to the Centers for Disease Control and Prevention (CDC). Although combating drug resistance is a multifaceted strategy, the key to resolving this issue is through the development of new antibiotics. The preliminary evaluation of novel epoxide derivative drugs targeted against sortase A involved in the pathogenesis of the foodborne bacteria Listeria monocytogenes will be presented.