Event Title

Synthesis and Evaluation of Sortase A Inhibitors

Research Mentor(s)

Amanda Murphy

Description

Each year, an increasing number of antibiotics become less effective in combating infectious bacterial diseases as a result of the prolonged and wide spread use of these drugs as treatments. As a result of an increasing number of drug resistant strains of bacteria, at least 2 million people in the United States acquire infectious diseases from drug resistant bacteria each year that are potentially fatal according to the Centers for Disease Control and Prevention (CDC). Although combating drug resistance is a multifaceted strategy, the key to resolving this issue is through the development of new antibiotics. The preliminary evaluation of novel epoxide derivative drugs targeted against sortase A involved in the pathogenesis of the foodborne bacteria Listeria monocytogenes will be presented.

Document Type

Event

Start Date

16-5-2018 9:00 AM

End Date

16-5-2018 12:00 PM

Location

Chemistry

Rights

Copying of this document in whole or in part is allowable only for scholarly purposes. It is understood, however, that any copying or publication of this document for commercial purposes, or for financial gain, shall not be allowed without the author’s written permission.

Language

English

Format

application/pdf

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May 16th, 9:00 AM May 16th, 12:00 PM

Synthesis and Evaluation of Sortase A Inhibitors

Chemistry

Each year, an increasing number of antibiotics become less effective in combating infectious bacterial diseases as a result of the prolonged and wide spread use of these drugs as treatments. As a result of an increasing number of drug resistant strains of bacteria, at least 2 million people in the United States acquire infectious diseases from drug resistant bacteria each year that are potentially fatal according to the Centers for Disease Control and Prevention (CDC). Although combating drug resistance is a multifaceted strategy, the key to resolving this issue is through the development of new antibiotics. The preliminary evaluation of novel epoxide derivative drugs targeted against sortase A involved in the pathogenesis of the foodborne bacteria Listeria monocytogenes will be presented.