Senior Project Advisor

Annelise Snyder

Document Type

Project

Publication Date

Spring 2025

Keywords

Celiac, Celiac Disease, Gluten, Autoimmunity, Tissue Transglutaminase, Immunotherapy, Medicine, Health Sciences, Biochemistry

Abstract

Celiac disease is an autoimmune disease with both allergy and autoimmune characteristics. It affects 0.5-1% of the population and is particularly common in Western countries. Symptoms include villous atrophy and malabsorption due to the tissue damage from inappropriate immune response. There is no cure, though celiac is typically treated with a strict, lifelong gluten free diet. The immune response in patients with celiac disease is predominantly caused by tissue transglutaminase enzyme activity and activated T cells in response to gluten ingestion, which kill intestine lining. Other therapies in research include immunotherapies and genetically modified wheat. This paper is a comprehensive review of the disease itself, the mechanism by which celiac presents clinical symptoms, as well as potential therapies or treatments.

Department

Biology

Type

Text

Rights

Copying of this document in whole or in part is allowable only for scholarly purposes. It is understood, however, that any copying or publication of this document for commercial purposes, or for financial gain, shall not be allowed without the author’s written permission.

Language

English

Format

application/pdf

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