Senior Project Advisor
Filip Jadogzinski
Document Type
Project
Publication Date
Spring 2022
Keywords
Protein, Indel, Mutation, Insertion, Deletion
Abstract
Insertion and deletion mutations (InDels) are an understudied dynamic of protein structure. Little real world data exists for these types of mutations. Computational modeling can help fill in these gaps and support researchers in obtaining and analyzing data. In this paper, we present a unique approach to gathering exhaustive data on InDel mutations to create heat maps and other visualizations useful in analysis. Every possible InDel in a set of proteins is modelled in silico, rigidity data is obtained for all of those computational InDels, and the rigidity data of each is then compared to that of the wildtype, providing a complete computational map for what happens for any given InDel mutation in a protein. We provide visualizations of this data, in particular a heat map that will showcase the structural impact of every possible insertion mutation in a given protein.
Department
Computer Science
Recommended Citation
Martin, Lilu, "Indel Mapping" (2022). WWU Honors College Senior Projects. 589.
https://cedar.wwu.edu/wwu_honors/589
Subjects - Topical (LCSH)
Proteins--Computer simulation; Mutation (Biology)--Computer simulation; Information visualization
Genre/Form
essays
Type
Text
Rights
Copying of this document in whole or in part is allowable only for scholarly purposes. It is understood, however, that any copying or publication of this document for commercial purposes, or for financial gain, shall not be allowed without the author’s written permission.
Language
English
Format
application/pdf