Senior Project Advisor
Autism spectrum disorder, medical cannabis, cannabidiol, terpenes, brain-derived neurotrophic factor, BTBR mouse model, social behavior
Cannabis-based medicines have emerged as a promising therapeutic for a variety of neuropsychiatric disorders, including autism spectrum disorder (ASD). This manuscript encompasses research investigating the application of the phytocannabinoid cannabidiol (CBD) in treating core symptoms of ASD. Chapter one includes a literature review of the neurodevelopmental etiology and current pharmacological strategies for ASD. The second chapter is a paper illustrating the prosocial effects of CBD and cannabis-inspired terpenes in our mouse model of ASD. The third chapter is a pilot study looking into the developmental pathology and adolescent exposure to CBD as an interventional strategy in our preclinical model. This work and continued research can inform cannabis-based treatments for ASD in the effort to improve quality of life and offer wider accessibility to medications for affected individuals.
Staben, Jenika and Kaplan, Josh, "Developmental intervention with CBD on BDNF levels and prosocial behavior in a mouse model of autism spectrum disorder" (2023). WWU Honors College Senior Projects. 653.
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