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Date of Award

Summer 2023

Document Type

Masters Thesis

Degree Name

Master of Science (MS)

Department

Environmental Sciences

First Advisor

Sofield, Ruth M.

Second Advisor

James, C. Andrew

Third Advisor

Harding, Louisa B.

Fourth Advisor

Sobocinski, Kathryn L.

Abstract

Contaminants of emerging concern (CECs) are chemicals used in daily life, such as pharmaceuticals, personal hygiene products, steroids, pesticides, and flame retardants. The environmental occurrence and toxicology of CECs are poorly characterized, and they are generally unregulated. Traditional toxicological approaches rely on in vivo methods to test whole organisms for apical endpoints, including survival, reproduction, and growth. This is time-consuming and costly, both financially and in terms of laboratory animal well-being, limiting ecotoxicological data for CECs. To overcome this challenge, we are utilizing alternative approaches, including New Approach Methodologies (NAMs), to perform a screening-level evaluation of CECs present in Puget Sound to prioritize those most likely to elicit a biological response in aquatic organisms.

Type

Text

Keywords

ToxCast, in vitro high throughput screening data, Biological effects, CECs, Screening, New Approach Methodologies, Estrogen agonism, Endocrine disruption

Publisher

Western Washington University

OCLC Number

1393035157

Subject – LCSH

Pollutants--Washington (State)--Puget Sound; Environmental toxicology--Washington (State)--Puget Sound; Toxicity testing--In vivo; Endocrine disrupting chemicals--Washington (State)--Puget Sound

Geographic Coverage

Puget Sound (Wash.)

Format

application/pdf

Genre/Form

masters theses

Language

English

Rights

Copying of this document in whole or in part is allowable only for scholarly purposes. It is understood, however, that any copying or publication of this document for commercial purposes, or for financial gain, shall not be allowed without the author’s written permission.

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