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Date of Award
Master of Science (MS)
Sofield, Ruth M.
James, C. Andrew
Harding, Louisa B.
Sobocinski, Kathryn L.
Contaminants of emerging concern (CECs) are chemicals used in daily life, such as pharmaceuticals, personal hygiene products, steroids, pesticides, and flame retardants. The environmental occurrence and toxicology of CECs are poorly characterized, and they are generally unregulated. Traditional toxicological approaches rely on in vivo methods to test whole organisms for apical endpoints, including survival, reproduction, and growth. This is time-consuming and costly, both financially and in terms of laboratory animal well-being, limiting ecotoxicological data for CECs. To overcome this challenge, we are utilizing alternative approaches, including New Approach Methodologies (NAMs), to perform a screening-level evaluation of CECs present in Puget Sound to prioritize those most likely to elicit a biological response in aquatic organisms.
ToxCast, in vitro high throughput screening data, Biological effects, CECs, Screening, New Approach Methodologies, Estrogen agonism, Endocrine disruption
Western Washington University
Subject – LCSH
Pollutants--Washington (State)--Puget Sound; Environmental toxicology--Washington (State)--Puget Sound; Toxicity testing--In vivo; Endocrine disrupting chemicals--Washington (State)--Puget Sound
Puget Sound (Wash.)
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Faber, Maya, "Contaminants of Emerging Concern in Puget Sound: Screening, Prioritization, and Estrogenic Mixture Response Assessment" (2023). WWU Graduate School Collection. 1229.