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Date of Award

Summer 2023

Document Type

Masters Thesis

Degree Name

Master of Science (MS)


Environmental Sciences

First Advisor

Sofield, Ruth M.

Second Advisor

James, C. Andrew

Third Advisor

Harding, Louisa B.

Fourth Advisor

Sobocinski, Kathryn L.


Contaminants of emerging concern (CECs) are chemicals used in daily life, such as pharmaceuticals, personal hygiene products, steroids, pesticides, and flame retardants. The environmental occurrence and toxicology of CECs are poorly characterized, and they are generally unregulated. Traditional toxicological approaches rely on in vivo methods to test whole organisms for apical endpoints, including survival, reproduction, and growth. This is time-consuming and costly, both financially and in terms of laboratory animal well-being, limiting ecotoxicological data for CECs. To overcome this challenge, we are utilizing alternative approaches, including New Approach Methodologies (NAMs), to perform a screening-level evaluation of CECs present in Puget Sound to prioritize those most likely to elicit a biological response in aquatic organisms.




ToxCast, in vitro high throughput screening data, Biological effects, CECs, Screening, New Approach Methodologies, Estrogen agonism, Endocrine disruption


Western Washington University

OCLC Number


Subject – LCSH

Pollutants--Washington (State)--Puget Sound; Environmental toxicology--Washington (State)--Puget Sound; Toxicity testing--In vivo; Endocrine disrupting chemicals--Washington (State)--Puget Sound

Geographic Coverage

Puget Sound (Wash.)




masters theses




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