Senior Project Advisor
Jeff Carroll
Document Type
Project
Publication Date
Spring 2023
Keywords
Huntington's disease, Antisense oligonucleotides, Neurodegenerative, Allele-selective
Abstract
Huntington's disease (HD) is a uniformly fatal, neurodegenerative disease originating from a mutation in one allele of the HTT gene. While global HTT reduction has shown some improvement in treating the progression of HD, the wild type HTT allele has necessary functions for survival and cannot be ablated. Antisense oligonucleotides (ASOs) are a way to target pre-MRNA and prevent the mRNA's translation into a protein. In this study, we examined the efficacy of allele selective ASOs in comparison to pan ASOs in ameliorating HD pathology and symptomology.
Department
Behavioral Neuroscience
Recommended Citation
Berry, Sage, "Hunting Down Treatment Therapies for Huntington's Disease" (2023). WWU Honors College Senior Projects. 658.
https://cedar.wwu.edu/wwu_honors/658
Subjects - Topical (LCSH)
Huntington's disease; Nervous system--Degeneration; Oligonucleotides
Type
Text
Rights
Copying of this document in whole or in part is allowable only for scholarly purposes. It is understood, however, that any copying or publication of this document for commercial purposes, or for financial gain, shall not be allowed without the author’s written permission.
Language
English
Format
application/pdf